Jim L. Rupert

		Office:	Wesbrook Building - Rm 346, 6174 University Blvd
		Phone:	604-822-8462
		Fax:	604-822-9451
		Lab:	Genes, RNA, Informatics, and Protein (GRIP) Laboratory
		Lab Ph:	604-827-3411
		EMail:	rupertj@interchange.ubc.ca
Assistant Professor

Background

University of Guelph B.Sc. (Genetics) 1984, University of Toronto M.Sc. (Medical Genetics) 1988, University of British Columbia Ph.D. (Zoology) 2000, Post-doctoral Fellow U.B.C, Dept Pathology and Laboratory Medicine 2000-2003, Post-doctoral Fellow Terry Fox Laboratory, B.C. Cancer Agency 2003-2004

Specialization

Genetics and genomics of exercise. Human adaptation to altitude and the genetics of altitude-related illnesses. Genetic approaches to “doping” control.

Cross-appointed to the Genetics Graduate Program.

Associate Chair, Behavioural Research Ethics Board

Courses Taught

HKIN 190/191 - Functional Anatomy and Applied Physiology

HKIN 489 Genetic Issues in Sports and Exercise Science

Research

Current research projects:

1) The genetics of acute mountain sickness in the Nepalese

2) The genetics of risk taking behavior in skiers and snowboarders.

3) Angiotensin converting enzyme (ACE): the role of genotype, plasma concentration, and inhibition on physical performance.

4) Development of a prototype blood-based test for exogenous erythropoietin activity based on transcriptional profiling (funded by the World Anti-Doping Agency).

5) Comparative genetics of highland and lowland camilids (llama vs. camels)

Future projects (call if you’re interested…)

1) Twin studies of hypoxia response and acclimatisation

Recent (this Millennia) publications and invited presentations

Peer-reviewed publications

Wang P, Fedoruk MN, Rupert JL. 2008 Keeping Pace With Ace: Are Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers Potential Doping Agents? Sports Med. (In press)

Rupert JL. 2008 Genomics and altitude research: what (and how) can we learn from the transcriptome. High Alt Med Biol (In press)

Sporer BC, Sheel AW, Taunton, J. Rupert, JL, McKenzie DC. 2008. Inhaled Salbutamol and Doping Control: Effects of Dose on Urine Concentrations. Clinical Journal of Sports Medicine (In press)

Fedoruk MN, Rupert JL. 2008. Myostatin Inhibition: A Potential Performance Enhancement Strategy? Scand J Med Sci Sports (Feb 1; [Epub ahead of print])

Witt JD, Guenette JA, Rupert JL, McKenzie DC, Sheel AW. 2008. Inspiratory muscle training attenuates the human respiratory muscle metaboreflex. J. Physiol. 584(Pt 3):1019-28.

Wang P, Koehle MS, Rupert JL. 2007 Common haplotypes in the beta-2 adrenergic gene are not associated with acute mountain sickness susceptibility in Nepalese. High Alt. Med. Biol. 8(3): 206-212.

Rupert JL and Koehle MS. 2006. The evidence for a genetic basis for altitude-related illness High Alt. Med. Biol, 7(2): 150-167

Koehle MS, Wang P, Guenette JA, Rupert JL. 2006. No association between variants in the ACE and angiotensin II receptor 1 gene and acute mountain sickness in Nepalese pilgrims to the Janai Purnima Festival at 4380 metres. High Alt. Med. Biol. 7(4):281 – 289.

Siddiqui A, Khattra J, Delaney A, Zhao Y, Astell C, Asano J, Babakaiff R, Barber S, Beland J, Brown-John M, Chand S, Charters A, Cullum R, Dhalla N, Featherstone R, Hoffman B, Holt R, Lee S, Luis de Algara T, Ma K, Matsuo C, Mayo M, McDonald H, Prabhu A, Pandoh P, Rupert JL, Smailus D, Stott J, Tsai M, Wong D, Wu M, Yang G, Zhang I, Hirst M, Jones S, Helgason C, Simpson E, Hoodless P, Marra, M. 2005. A Mouse Atlas of Gene Expression: A public large-scale digital gene expression profiling resource from precisely defined developing C57BL/6J mouse tissues and cells. Proc Acad Natl Sci (USA) 102(51): 18485-18490.

Rupert JL. 2003. The search for genotypes that underlie human performance phenotypes. Comp. Biochem. Physiol. A 136: 191-203.

Rupert JL, Monsalve MV, Kidd KK, Tan C, Hochachka PW, Devine DV. 2003. Selective pressure has not acted against hypercoagulability alleles in high-altitude Amerindians. Ann. Hum. Genet. 67(5): 426-432.

Monsalve MV, Salzano FM, Rupert JL, Hutz MH, Hill K, Hurtado AM, Hochachka PW, Devine DV. 2003. Methylenetetrahydrofolate reductase (MTHFR) allele frequencies in Amerindians. Ann. Hum. Genet. 67(4): 367-371.

Hochachka PW, Rupert JL. 2003. Fine Tuning the HIF-1 'Global' O2 sensor for hypobaric hypoxia in Andean high-altitude natives. BioEssays. 25(5) 515-519.

Rupert JL, Kidd K, Norman LE, Monsalve MV, Hochachka PW, Devine DV. 2003. Genetic polymorphisms in the Renin-Angiotensin system in high-altitude and low-altitude Native American populations. Ann. Hum. Genet. 67(1):17-25.

Hochachka PW, Rupert JL, Goldenberg L, Gleave M, Kozlowski P. 2002. Going malignant: the hypoxia connection in prostate cancer. BioEssays 24 749-757.

Rupert JL, Hochachka PW. 2001. Genetic approaches to understanding human adaptation in the Andes. J. Exp. Biol. 204: 3151-3160.

Rupert JL, Hochachka PW. 2001. The evidence for hereditary factors contributing to high altitude adaptation in Andean natives: a review. High Alt. Med. Biol. 2(2): 235-256.

Rupert JL, Monsalve MV, Devine DV, Hochachka PW. 2000. Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population. Ann. Hum. Genet. 64 135–143.

Invited presentations

Development of a prototype blood-based test for exogenous erythropoietin activity based on transcriptional profiling. Genome BC, Vancouver, Canada, 2007.

Genetic variation and adaptation in a high altitude Andean population: single nucleotide polymorphisms and association analysis. IV World Congress on Mountain Medicine and High Altitude Physiology, Arica,
Chile, 2000.

Genetic adaptations to living in hypoxia: lessons from the Andes.
Journal of Experimental Biology Conference (Physiological Limits to Human Performance), Flagstaff, Arizona, 2000.