Jim L. Rupert

		Office:	Wesbrook Building - Rm 346, 6174 University Blvd
		Phone:	604-822-8462
		Fax:	604-822-9451
		Lab:	Genes, RNA, Informatics, and Protein (GRIP) Laboratory
		Lab Ph:	604-827-3411
		EMail:	rupertj@interchange.ubc.ca
Associate Professor

Background

University of Guelph B.Sc. (Genetics) 1984, University of Toronto M.Sc. (Medical Genetics) 1988, University of British Columbia Ph.D. (Zoology) 2000, Post-doctoral Fellow U.B.C, Dept Pathology and Laboratory Medicine 2000-2003, Post-doctoral Fellow Terry Fox Laboratory, B.C. Cancer Agency 2003-2004

Specialization

Genetics and genomics of exercise. Human adaptation to altitude and the genetics of altitude-related illnesses. Genetic approaches to “doping” control.

Cross-appointed to the Genetics Graduate Program.

Associate Chair, UBC Behavioural Research Ethics Board

Courses Taught

HKIN 191 - Functional Anatomy and Applied Physiology II

HKIN 489B - Genetic Issues in Sports and Exercise Science

Research

Current research projects:

1) The genetics of acute mountain sickness in the Nepalese

2) The genetics of risk taking behavior in skiers and snowboarders.

3) Angiotensin converting enzyme (ACE): the role of genotype, plasma concentration, and inhibition on physical performance.

4) Development of a prototype blood-based test for exogenous erythropoietin activity based on transcriptional profiling (funded by the World Anti-Doping Agency).

Future projects (call if you’re interested…)

1) Twin studies of hypoxia response and acclimatisation

Funding Sources

World Anti-Doping Agency (WADA)

Canadian Fund for Innovation (CFI)

Martha Piper Research Fund (P.I. Dr William Sheel)

BC Mental Health and Addictions Research Network

 

Recent (this Millennium) publications and invited presentations

publications

Wang P, Ha AYN, Kidd KK, Koehle MS, Rupert JL. 2009. A variant of the endothelial nitric oxide synthase gene (NOS3) associated with AMS susceptibility is less common in the Quechua, a high-altitude native population. High Alt Med Biol (in press)

Brown CJ, Rupert JL. 2009. Epigenetics and the role of epigenetic changes in hypoxia-induced gene expression. in Hypoxia and Exercise: Proceedings of the 16th International Hypoxia Symposium ed. Editors: RC Roach, PD Wagner, PH Hackett. Springer Academic Publishers, New York (in press)

Schneider AJ, Rupert JL. 2009. Constructing winners: the science and ethics of genetically manipulating athletes J Philos Sport (in press)

Rupert JL. 2009. Transcriptional profiling: a potential anti-doping strategy. Scand J Med Sci Sports. [Jun 23. Epub ahead of print]

Wang P, Koehle MS, Rupert JL. 2009. Genotype at the Missense G894T Polymorphism (Glu298Asp) in the NOS3 Gene is Associated with the Susceptibility to Acute Mountain Sickness. High Alt Biol Med (In press)

Querido JS, Rupert JL, McKenzie DC, Sheel AW. 2009 Effects of intermittent hypoxia on the cerebrovascular responses to submaximal exercise in humans. Eur J Appl Physiol. Feb;105(3):403-9.

Wang P, Fedoruk MN, Rupert JL. 2008 Keeping Pace With Ace: Are Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers Potential Doping Agents? Sports Med. 38(12):1065-79.

Rupert JL. 2008 Genomics and altitude research: what (and how) can we learn from the transcriptome. High Alt Med Biol 9(2):115-22.

Sporer BC, Sheel AW, Taunton, J. Rupert, JL, McKenzie DC. 2008. Inhaled Salbutamol and Doping Control: Effects of Dose on Urine Concentrations. Clinical Journal of Sports Medicine 18(3):282-5.

Fedoruk MN, Rupert JL. 2008. Myostatin Inhibition: A Potential Performance Enhancement Strategy? Scand J Med Sci Sports, 2008 Apr;18(2):123-31.

Witt JD, Guenette JA, Rupert JL, McKenzie DC, Sheel AW. 2007. Inspiratory muscle training attenuates the human respiratory muscle metaboreflex. J. Physiol. 584(Pt 3):1019-28.

Wang P, Koehle MS, Rupert JL. 2007 Common haplotypes in the beta-2 adrenergic gene are not associated with acute mountain sickness susceptibility in Nepalese. High Alt. Med. Biol. 8(3): 206-212.

Rupert JL and Koehle MS. 2006. The evidence for a genetic basis for altitude-related illness High Alt. Med. Biol, 7(2): 150-167

Koehle MS, Wang P, Guenette JA, Rupert JL. 2006. No association between variants in the ACE and angiotensin II receptor 1 gene and acute mountain sickness in Nepalese pilgrims to the Janai Purnima Festival at 4380 metres. High Alt. Med. Biol. 7(4):281 – 289.

Siddiqui A, Khattra J, Delaney A, Zhao Y, Astell C, Asano J, Babakaiff R, Barber S, Beland J, Brown-John M, Chand S, Charters A, Cullum R, Dhalla N, Featherstone R, Hoffman B, Holt R, Lee S, Luis de Algara T, Ma K, Matsuo C, Mayo M, McDonald H, Prabhu A, Pandoh P, Rupert JL, Smailus D, Stott J, Tsai M, Wong D, Wu M, Yang G, Zhang I, Hirst M, Jones S, Helgason C, Simpson E, Hoodless P, Marra, M. 2005. A Mouse Atlas of Gene Expression: A public large-scale digital gene expression profiling resource from precisely defined developing C57BL/6J mouse tissues and cells. Proc Acad Natl Sci (USA) 102(51): 18485-18490.

Rupert JL. 2003. The search for genotypes that underlie human performance phenotypes. Comp. Biochem. Physiol. A 136: 191-203.

Rupert JL, Monsalve MV, Kidd KK, Tan C, Hochachka PW, Devine DV. 2003. Selective pressure has not acted against hypercoagulability alleles in high-altitude Amerindians. Ann. Hum. Genet. 67(5): 426-432.

Monsalve MV, Salzano FM, Rupert JL, Hutz MH, Hill K, Hurtado AM, Hochachka PW, Devine DV. 2003. Methylenetetrahydrofolate reductase (MTHFR) allele frequencies in Amerindians. Ann. Hum. Genet. 67(4): 367-371.

Hochachka PW, Rupert JL. 2003. Fine Tuning the HIF-1 'Global' O2 sensor for hypobaric hypoxia in Andean high-altitude natives. BioEssays. 25(5) 515-519.

Rupert JL, Kidd K, Norman LE, Monsalve MV, Hochachka PW, Devine DV. 2003. Genetic polymorphisms in the Renin-Angiotensin system in high-altitude and low-altitude Native American populations. Ann. Hum. Genet. 67(1):17-25.

Hochachka PW, Rupert JL, Goldenberg L, Gleave M, Kozlowski P. 2002. Going malignant: the hypoxia connection in prostate cancer. BioEssays 24 749-757.

Rupert JL, Hochachka PW. 2001. Genetic approaches to understanding human adaptation in the Andes. J. Exp. Biol. 204: 3151-3160.

Rupert JL, Hochachka PW. 2001. The evidence for hereditary factors contributing to high altitude adaptation in Andean natives: a review. High Alt. Med. Biol. 2(2): 235-256.

Rupert JL, Monsalve MV, Devine DV, Hochachka PW. 2000. Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population. Ann. Hum. Genet. 64 135–143.

Invited presentations

Rupert JL. Constructing winners: the science and ethics of genetically manipulating athletes. Langara College's Sport and Technology: Philosophical Dimensions Conference, Vancouver, June 2009.

Rupert, JL Gene doping: Genes, doping, and construction of future athletes. Association of National Anti-doping Organizations workshop, Vancouver Nov 2008.

Rupert, JL. Genes, doping, and construction of future athletes. BC Association of Kinesiologists AGM, Vancouver Oct 2008.

Rupert, JL. Transgendered athletes in the Olympics (presentation and panellist) Faculty of Law, University of Victoria, Victoria, Jan 2008.

Rupert, JL. Hypoxia, EPO, and new strategies in doping control Department of Zoology, University of British Columbia, March 2007.

Rupert JL. Development of a prototype blood-based test for exogenous erythropoietin activity based on transcriptional profiling. Genome BC, Vancouver, 2007.

Rupert JL. Genetic variation and adaptation in a high altitude Andean population: single nucleotide polymorphisms and association analysis. IV World Congress on Mountain Medicine and High Altitude Physiology, Arica, Chile, 2000.

Rupert JL. Genetic adaptations to living in hypoxia: lessons from the Andes. Journal of Experimental Biology Conference (Physiological Limits to Human Performance), Flagstaff, Arizona, 2000.